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I’m assuming his ear infections are impacting his hearing. So he’s likely not ignoring you or misunderstanding you, rather he’s just not hearing you. Keep up with the doctors appointments and good luck.
Can you pop into your local child health clinic with these concerns? They can probably do an assessment as well to see if he's meeting milestones with speech and following commands!
I would take all of your concerns to a good Dr and get referrals for hearing checks and a pediatrician
He may have a hearing problem from the constant ear infections, and he is probably in pain from it as well.
His actions would be typical of frustration and / or pain.
Lots of kids have ear problems, and some have to have grommets inserted to drain their ears.
Without it they can end up with permanent hearing impairments, and that will hinder their progress at school.
ENT should be able to sort it out.
One of mine had ear infections, but the antibiotics worked for him.